Characterization of Ca Channels in Rat Subthalamic Nucleus Neurons
نویسندگان
چکیده
WEN-JIE SONG, YOSUKE BABA, TAKESHI OTSUKA, AND FUJIO MURAKAMI Department of Electronic Engineering, Graduate School of Engineering, Osaka University, Suita 565-0871; and Division of Biophysical Engineering, Graduate School of Engineering Science and Core Research for Evolutional Science and Technology/Murakami Laboratory, Center for Advanced Research Projects, Osaka University, Toyonaka 560-8531, Japan
منابع مشابه
Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.
An increase in neuronal burst activities in the subthalamic nucleus (STN) is a well-documented electrophysiological feature of Parkinson disease (PD). However, the causal relationship between subthalamic bursts and PD symptoms and the ionic mechanisms underlying the bursts remain to be established. Here, we have shown that T-type Ca(2+) channels are necessary for subthalamic burst firing and th...
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Potassium channels are trans-membrane proteins, which selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitability cells and signal transduction pathways. Bothutous Schach (BS) scorpion venom consists of several polypeptides that could modulate ion channels. In this study, the effects of BS crude venom on passive and active electrophysiolo...
متن کاملCharacterization of Ca(2+) channels in rat subthalamic nucleus neurons.
The subthalamic nucleus (STN) plays a key role in motor control. Although previous studies have suggested that Ca(2+) conductances may be involved in regulating the activity of STN neurons, Ca(2+) channels in this region have not yet been characterized. We have therefore investigated the subtypes and functional characteristics of Ca(2+) conductances in STN neurons, in both acutely isolated and ...
متن کاملThe Effects of Buthotus schach Scorpion Venom on Electrophysiological Properties of Magnocellular Neurons of Rat Supraoptic Nucleus
Potassium channels are trans-membrane proteins, which selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitability cells and signal transduction pathways. Bothutous Schach (BS) scorpion venom consists of several polypeptides that could modulate ion channels. In this study, the effects of BS crude venom on passive and active electrophysiolo...
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Midbrain periaqueductal gray mater area (PAG) receives some afferents from anterolateral system, frontal cortex, and hypothalamus that inhibit pain through its descending pathway that synapses medial raphe nuclus (mrph) and finally terminates on spinal cord enkephalinergic interneurons in layers II and III. In the present study, the role of Ca+2–channels located on medial raphe nucleus neurons ...
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